2020-09-23

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The role of opioidergic system in controlling gonadotropin secretion in elderly men still remains uncertain. In the present study, we attempted to examine the opioidergic inhibitory tone imposed Evidence of increased opioidergic tone as a potential cause of pruritus in PBC led to studies using opioid antagonists as third-line therapy, such as 25 to 50 mg/day naltrexone. 117 This has been dampened by adverse side effects including an opioid withdrawal–like reaction, pain, and confusion. Opioidergic modulation of the oestradiol-induced LH surge in the rat: roles of ovarian steroids. Sex steroids convey information on the status of the reproductive system, which the brain is able to integrate to promote ovulation, in the form of the LH surge. The present studies examined the influence of alterations in central opioidergic tone to 1998-06-01 The increase in opioidergic tone by the central administration of morphine, which binds to the mu opioid receptor, is associated with pruritus.

Opioidergic tone

Author information: (1)Boston Children's Hospital, Box 9, 1 Autumn Street, Boston MA 02215. Comment on Pain. 2017 Feb;158(2):212-219. PMCID: PMC5240808 PMID: 28092322 [Indexed for MEDLINE] Publication Types: Comment; MeSH terms Lippincott Journals Subscribers, use your username or email along with your password to log in., use your username or email along with your password to log in. Reduced thermal sensitivity and increased opioidergic tone in the TASTPM mouse model of Alzheimer's disease. Aman Y(1), Pitcher T, Simeoli R, Ballard C, Malcangio M. Author information: (1)Wolfson Centre for Age Related Diseases, King's College London, London, United Kingdom. An opioidergic agent (or drug) is a chemical which functions to directly modulate the opioid neuropeptide systems (i.e., endorphin, enkephalin, dynorphin, nociceptin) in the body or brain.

The present studies examined the influence of alterations in central opioidergic tone to 1998-06-01 The increase in opioidergic tone by the central administration of morphine, which binds to the mu opioid receptor, is associated with pruritus. Pruritus is a symptom of cholestasis, which appears to result, in part, from increased opioidergic tone; a central mechanism has been proposed.

A central mechanism associated with increased opioidergic tone and involving activation of itch centres in the brain has been postulated. 19, 65 Findings consistent with such a concept include: (i) the plasma and dermal interstitial fluid concentrations of bile acids do not correlate with the subjective severity of the itch; 66 (ii) in cholestasis, plasma enkephalin concentrations are

This prospective, uncontrolled study was done to determine the efficacy of intravenous naloxone in pruritus of acute cholestasis. Twenty-two patients with severe pruritus (based on visual analogue scale [VAS] score of 0–100 and associated symptoms) were treated with intravenous naloxone (0.4 mg every 8 hours) for at least 48 hours. An opposite shift of opioidergic function would also have to be considered in any treatment of a patient with fibromyalgia. These patients may be emotionally unresponsive due to an autoimmune hormonal disorder that diminishes opioid tone (Ramanathan et al., 2012; Johnson et al., 2014).

Mar 4, 2020 enhanced opioidergic tone in cholestasis: (i) the opiate withdrawal-like response caused by an opiate antagonist in patients with choles-.

Feb 1, 2018 Opioidergic Tone and Pain Susceptibility: Interactions between Reward Systems and Opioid Receptors · Opioid Receptor SNPs and Pain. We then examined whether OFQ would produce hyperalgesia in the absence of such an endogenous opioidergic tone.Neither naloxone (1 mg kg-1 ; s.c.) nor May 12, 2011 pain control system and is the main site of the opioidergic analgesia. depends on spinal GABAergic and glycinergic tone: implications for A tonic opioidergic tone within the PAG was revealed in adult rats by intra-PAG microinjection of CTOP. (120 ng, MOR antagonist), which lowered mechanical during which lever pressing elicited the presentation of the light/tone CS. provide evidence that dopaminergic and opioidergic signaling in the NAcc regulate crease in the opioidergic tone of the hypothalamus which is the cause of decreased GnRH secretion and a subsequent reduction of LH release (Ferin et. 2021年2月2日 that enhanced endogenous opioidergic tone in the anterior insula may buffer negative affective states in depressed individuals, a mechanism This may argue for an elevated opioidergic tone in the brain of athletes, mediating antinociceptive mechanisms. Our findings provide the first evidence using Endogenous opioidergic dysregulation of pain in fibromyalgia: a or affinity.30 That high endogenous opioid tone likely translates to loss of MOR availability. Recabarren, S. E.; Zapata, P.; Parilo, J.: Disappearance of Opioidergic Tone on LH Secretion in Underfed Prepubertal Sheep.

Following the naloxone administration in bile duct resected animals, striking opioid withdrawal signs are observed due to increased opioidergic tone. Pretreatment of animals with L-nitro arginine, a nitric oxide synthase inhibitor, reduces the naloxone-precipitated withdrawal signs as … 2002-08-01 Opioidergic. Opioidergic descending pain control in the hypothalamus, PAG and RVM underlied placebo analgesia using MRI [173]. From: Peptides, 2010.
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This may argue for an elevated opioidergic tone in the brain of athletes, mediating antinociceptive mechanisms. central opioidergic tone after rapid fentanyl infusion.1–3 Pain, pruritus, cough, and probably many othersignalsfrom theperiphery,aremodulated Address reprint requests to: Zbigniew Zylicz, MD, PhD, Hospice Rozenheuvel, Rosendaalselaan 20, 6891 DD Rozendaal, The Netherlands. Accepted for publication: June 16, 2003. 2018-09-27 2010-01-27 2004-02-01 central opioidergic tone contributes to the pruritus of cholestasis provide a rationale for treating this form of pruritus with opiate antagonists. However, initiation of therapy with an opiate antagonist in a cholestatic patient may precipitate a transient opioid withdrawal– like reaction.

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The present studies examined the influence of alterations in central opioidergic tone to initiate the LH surge, and the roles of oestradiol and progesterone to effect changes in opioidergic tone, by antagonizing this activity using either naloxone or nalmefene (N-cyclopropylmethyl-6-desoxy-6-methylene-noroxy-morphone), a long-acting mu- and kappa-opiate antagonist.

This approach was based on evidence that patients with AD show increased CSF levels of opioid peptides and a reduction in opioid binding receptors in the dentate gyrus. 20,29,33 In this study, the opioid receptor antagonist, naloxone, induced an increase in sensitivity to thermal stimulation suggesting that increased opioidergic tone in the Lippincott Journals Subscribers, use your username or email along with your password to log in., use your username or email along with your password to log in.

increase in opioidergic tone (and thus no danger of a withdrawal syndrome if an opioid antagonist is given). Instead, the ratio between m-opioid (pruritus-inducible) and k-opioid (pruritus-suppressive) re-ceptors alters in favor of the former.69,70 This predisposes to the onset or exacerbation of pruritus. It 2

In the present study, we attempted to examine the opioidergic inhibitory tone imposed Evidence of increased opioidergic tone as a potential cause of pruritus in PBC led to studies using opioid antagonists as third-line therapy, such as 25 to 50 mg/day naltrexone. 117 This has been dampened by adverse side effects including an opioid withdrawal–like reaction, pain, and confusion. Opioidergic modulation of the oestradiol-induced LH surge in the rat: roles of ovarian steroids. Sex steroids convey information on the status of the reproductive system, which the brain is able to integrate to promote ovulation, in the form of the LH surge.

However, luteinizing hormone (LH) pulse frequency and pulse amplitude were not affected by naloxone treatment.